Detective Charlie Hudson teams up with what he calls his "highly trained law enforcement animal" German Shepherd dog named Rex who he prefers to team up with because he doesn't talk his ear off.
When a controversial university professor is found dead in his classroom, Charlie and Rex investigate leads while Jesse goes undercover and soon finds himself danger.
When a professional pet sitter is killed by a tree while looking after a tiny dog, Hudson and Rex take the case and discover everything from blackmail to a foot fetish.
With a gallery curator found murdered on his showroom floor and a missing sculpture, Charlie, Rex and Sarah are thrown into the world of high art. Jesse feels the burn when Sarah picks him as her new running buddy.
A pair of activists break into a water bottling factory to get their message across when one is killed. But who did it? It's up to Hudson and Rex to find out.
Charlie and Rex investigate a death that seems to be connected to a rehab centre whose practices allegedly border on those of a religious cult, more than a rehab clinic.
While investigating a car accident Charlie and Rex are told about strange lights in the sky. What they find turns out to be more science, than the fiction suggested by the title.